My research interests include understanding how proteins allosterically transduce signal. To this end, I am employing a variety of computational methods. In particular, I am interested in the activation dynamics of a biomedically important class of molecules, G protein-coupled receptors. These integral membrane proteins transduce signal across the cell membrane, but the allosteric mechanism of their activation is not fully understood. I am applying molecular dynamics simulations and elastic network models to track structural transitions associated with activation/deactivation of a model receptor, rhodopsin. I am also interested in the development of novel methods for tracking structural transitions and analyses that allow us to directly compare simulation data to experimental observables. Leveraging multiple time-scale models I hope to produce a better picture of the allosteric cascade that connects the ligand-binding pocket to the protein’s active site.